Biology:3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase
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Short description: Enzyme
| 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.40 | ||||||||
| CAS number | 62213-58-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase is an enzyme that catalyzes the chemical reaction:[1]
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NAD+ + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + NADH + 2 H+
The 3 substrates of this enzyme are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NAD+, and H2O, whereas its 2 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, NADH, and H+. This enzyme participates in bile acid biosynthesis.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase. Other names in common use include:
- cholestanetriol-26-al 26-dehydrogenase,
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, dehydrogenase,
- trihydroxydeoxycoprostanal dehydrogenase,
- THAL-NAD oxidoreductase,
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+, and
- 26-oxidoreductase.
References
- ↑ "The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver". Biochim. Biophys. Acta 117 (1): 266–8. March 1966. doi:10.1016/0304-4165(66)90177-2. PMID 5914340.
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