Biology:INPP4B
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.[1]
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines.[2] There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=8821.
- ↑ "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications 440 (2): 277–82. October 2013. doi:10.1016/j.bbrc.2013.09.077. PMID 24070612.
Further reading
- "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research Communications 440 (2): 277–82. October 2013. doi:10.1016/j.bbrc.2013.09.077. PMID 24070612.
- "Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling". Cancer Cell 16 (2): 115–25. August 2009. doi:10.1016/j.ccr.2009.06.006. PMID 19647222.
- "Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer". Cancer Research 71 (2): 572–82. January 2011. doi:10.1158/0008-5472.CAN-10-2314. PMID 21224358.
- "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". The Journal of Biological Chemistry 272 (38): 23859–64. September 1997. doi:10.1074/jbc.272.38.23859. PMID 9295334.
- "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proceedings of the National Academy of Sciences of the United States of America 96 (7): 3640–5. March 1999. doi:10.1073/pnas.96.7.3640. PMID 10097090. Bibcode: 1999PNAS...96.3640M.
- "Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation". BMC Evolutionary Biology 10 (1): 351. November 2010. doi:10.1186/1471-2148-10-351. PMID 21070662. Bibcode: 2010BMCEE..10..351A.
- "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". The Journal of Biological Chemistry 270 (27): 16128–33. July 1995. doi:10.1074/jbc.270.27.16128. PMID 7608176.
- "Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations". Diabetes 56 (12): 3053–62. December 2007. doi:10.2337/db07-0457. PMID 17846126.
- "Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers". Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22231–6. December 2010. doi:10.1073/pnas.1015245107. PMID 21127264. Bibcode: 2010PNAS..10722231F.
- "Phosphatidylinositol signalling reactions". Seminars in Cell & Developmental Biology 9 (2): 153–60. April 1998. doi:10.1006/scdb.1997.0220. PMID 9599410.
- "INPP4B: the new kid on the PI3K block". Oncotarget 2 (4): 321–8. April 2011. doi:10.18632/oncotarget.260. PMID 21487159.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/INPP4B.
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