Biology:Plasmepsin I
From HandWiki
| Plasmepsin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.38 | ||||||||
| CAS number | 180189-87-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasmepsin I (EC 3.4.23.38, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule
This enzyme is present in the malaria organism, Plasmodium.
References
- ↑ "Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease". The Journal of Experimental Medicine 173 (4): 961–9. April 1991. doi:10.1084/jem.173.4.961. PMID 2007860.
- ↑ "Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase". The EMBO Journal 13 (2): 306–17. January 1994. doi:10.1002/j.1460-2075.1994.tb06263.x. PMID 8313875.
- ↑ "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation 93 (4): 1602–8. April 1994. doi:10.1172/JCI117140. PMID 8163662.
External links
- Plasmepsin+I at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
