Biology:THOP1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Thimet oligopeptidase is an enzyme that in humans is encoded by the THOP1 gene.

Further reading

• "Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide.". Biochem. Biophys. Res. Commun. 213 (1): 66–73. 1995. doi:10.1006/bbrc.1995.2099. PMID 7639763. 
• "Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.". Biochemistry 33 (1): 192–9. 1994. doi:10.1021/bi00167a025. PMID 8286339. 
• "Human thimet oligopeptidase". Biochem. J. 294 (Pt 2): 451–7. 1993. doi:10.1042/bj2940451. PMID 8373360. 
• Meckelein B; de Silva HA; Roses AD et al. (1997). "Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus". Genomics 31 (2): 246–9. doi:10.1006/geno.1996.0041. PMID 8824811. 
• Crack PJ; Wu TJ; Cummins PM et al. (1999). "The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane". Brain Res. 835 (2): 113–24. doi:10.1016/S0006-8993(99)01494-8. PMID 10415366. 
• Pineau C; McCool S; Glucksman MJ et al. (2000). "Distribution of thimet oligopeptidase (E.C. 3.4.24.15) in human and rat testes". J. Cell Sci. 112 (20): 3455–62. doi:10.1242/jcs.112.20.3455. PMID 10504294. 
• "Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15)". DNA Cell Biol. 18 (10): 781–9. 1999. doi:10.1089/104454999314926. PMID 10541437. 
• Tullai JW; Cummins PM; Pabon A et al. (2001). "The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation". J. Biol. Chem. 275 (47): 36514–22. doi:10.1074/jbc.M001843200. PMID 10969067. 
• "Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase". Life Sci. 67 (5): 509–20. 2000. doi:10.1016/S0024-3205(00)00650-0. PMID 10993116. 
• Saric T; Beninga J; Graef CI et al. (2001). "Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase". J. Biol. Chem. 276 (39): 36474–81. doi:10.1074/jbc.M105517200. PMID 11479311. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Localization of EP24.15, a major liver kininase". J. Histochem. Cytochem. 51 (1): 125–7. 2003. doi:10.1177/002215540305100115. PMID 12502762. 
• York IA; Mo AX; Lemerise K et al. (2003). "The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation". Immunity 18 (3): 429–40. doi:10.1016/S1074-7613(03)00058-X. PMID 12648459. 
• Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• "Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization". J. Biol. Chem. 279 (19): 20480–9. 2004. doi:10.1074/jbc.M400795200. PMID 14998993. 
• Grimwood J; Gordon LA; Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G. 
• "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. 2004. doi:10.1101/gr.2122004. PMID 15231747. 
• "Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases". J. Biol. Chem. 279 (45): 46723–32. 2004. doi:10.1074/jbc.M406537200. PMID 15328361. 
• "EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor". Cell Biochem. Funct. 23 (3): 195–204. 2005. doi:10.1002/cbf.1176. PMID 15376229.