Biology:Nitroalkane oxidase
From HandWiki
Short description: Enzyme
| nitroethane oxidase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.7.3.1 | ||||||||
| CAS number | 9029-36-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a nitroalkane oxidase (EC 1.7.3.1) is an enzyme that catalyzes the chemical reaction
- a nitroalkane + H2O + O2 [math]\displaystyle{ \rightleftharpoons }[/math] an aldehyde or ketone + nitrite + H2O2
The 3 substrates of this enzyme are nitroalkane, H2O, and O2, whereas its 4 products are aldehyde, ketone, nitrite, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor. The systematic name of this enzyme class is nitroalkane:oxygen oxidoreductase. Other names in common use include nitroethane oxidase, NAO, and nitroethane:oxygen oxidoreductase. This enzyme participates in nitrogen metabolism.
References
- LITTLE HN (1951). "Oxidation of nitroethane by extracts from Neurospora". J. Biol. Chem. 193 (1): 347–58. doi:10.1016/S0021-9258(19)52460-7. PMID 14907722.
- "Purification and properties of nitroalkane oxidase from Fusarium oxysporum". J. Bacteriol. 133 (1): 53–8. 1978. doi:10.1128/jb.133.1.53-58.1978. PMID 22538.
- "Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2702–7. 2002. doi:10.1073/pnas.052527799. PMID 11867731.
- "Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase". Arch. Biochem. Biophys. 433 (1): 157–65. 2005. doi:10.1016/j.abb.2004.08.021. PMID 15581574.
- "Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase". J. Am. Chem. Soc. 127 (7): 2062–6. 2005. doi:10.1021/ja043542f. PMID 15713081.
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