Biology:Glycolipid transfer protein
From HandWiki
| Glycolipid transfer protein (GLTP) | |||||||||
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| Identifiers | |||||||||
| Symbol | GLTP | ||||||||
| Pfam | PF08718 | ||||||||
| InterPro | IPR014830 | ||||||||
| OPM superfamily | 84 | ||||||||
| OPM protein | 1swx | ||||||||
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Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.[1][2]
It was discovered by Raymond J. Metz and Norman S. Radin in 1980 and partially purified and characterized in 1982.[3][4]
Recent reviews on structure and possible function are available.[5][6]
This protein transports primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.
Human proteins containing this domain
GLTP; PLEKHA8; PLEKHA9;
References
- ↑ "Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses". Biochemistry 43 (43): 13805–15. November 2004. doi:10.1021/bi0492197. PMID 15504043.
- ↑ "Structural evidence for adaptive ligand binding of glycolipid transfer protein". Journal of Molecular Biology 355 (2): 224–36. January 2006. doi:10.1016/j.jmb.2005.10.031. PMID 16309699.
- ↑ "Glucosylceramide uptake protein from spleen cytosol". The Journal of Biological Chemistry 255 (10): 4463–7. May 1980. PMID 7372587. http://www.jbc.org/content/255/10/4463.long.
- ↑ "Purification and properties of a cerebroside transfer protein". The Journal of Biological Chemistry 257 (21): 12901–7. November 1982. PMID 7130186. http://www.jbc.org/content/257/21/12901.long.
- ↑ "Glycolipid transfer proteins and membrane interaction". Biochimica et Biophysica Acta (BBA) - Biomembranes 1788 (1): 267–72. January 2009. doi:10.1016/j.bbamem.2008.10.003. PMID 19007748.
- ↑ "Glycolipid transfer proteins". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1771 (6): 746–60. June 2007. doi:10.1016/j.bbalip.2007.01.011. PMID 17320476.
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