Biology:NLRP10

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP10 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.

Further reading

• "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.". Int. Immunol. 16 (6): 777–86. 2004. doi:10.1093/intimm/dxh081. PMID 15096476. 
• "PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.". J. Biol. Chem. 280 (23): 21720–5. 2005. doi:10.1074/jbc.M410057200. PMID 15817483. 
• "Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation". Nat. Immunology 24 (4): 585–594. 2023. doi:10.1038/s41590-023-01450-z. PMID 36941399. 
• "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. 2003. doi:10.1038/nri1086. PMID 12766759. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. 2003. doi:10.1038/nrm1019. PMID 12563287. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence.". Biochem. Genet. 47 (9–10): 665–70. 2009. doi:10.1007/s10528-009-9262-2. PMID 19544093. 
• "A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence.". Biochem. Genet. 47 (9–10): 665–70. 2009. doi:10.1007/s10528-009-9262-2. PMID 19544093.