Biology:DNM2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

Function

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.

Interactions

DNM2 has been shown to interact with:

• SHANK1,
• SHANK2, and
• SNX9.

Clinical relevance

Mutations in this gene have been associated to cases of acute lymphoblastic leukaemia, or congenital myopathy (centronuclear type).

Further reading

• Sever S (2003). "Dynamin and endocytosis.". Curr. Opin. Cell Biol. 14 (4): 463–7. doi:10.1016/S0955-0674(02)00347-2. PMID 12383797. 
• "Dynamin: characteristics, mechanism of action and function.". Cell. Mol. Biol. Lett. 7 (4): 1073–80. 2003. PMID 12511974. 
• "Dynamin at the actin-membrane interface.". Curr. Opin. Cell Biol. 15 (1): 31–9. 2003. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701. 
• "Dynamin II is involved in endocytosis but not in the formation of transport vesicles from the trans-Golgi network.". J. Biochem. 125 (4): 780–9. 1999. doi:10.1093/oxfordjournals.jbchem.a022349. PMID 10101292. 
• "Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex.". J. Immunol. 163 (6): 3037–44. 1999. PMID 10477567. 
• "Evidence that dynamin-2 functions as a signal-transducing GTPase.". J. Cell Biol. 150 (1): 145–54. 2000. doi:10.1083/jcb.150.1.145. PMID 10893263. 
• "The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.". Nat. Cell Biol. 3 (8): 755–60. 2001. doi:10.1038/35087075. PMID 11483962. 
• "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells.". J. Biol. Chem. 276 (41): 37802–8. 2001. doi:10.1074/jbc.M105087200. PMID 11502744. 
• "Dominant intermediate Charcot-Marie-Tooth neuropathy maps to chromosome 19p12-p13.2.". Am. J. Hum. Genet. 69 (4): 883–8. 2001. doi:10.1086/323743. PMID 11533912. 
• "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.". J. Biol. Chem. 276 (51): 48458–65. 2002. doi:10.1074/jbc.M104927200. PMID 11583995. 
• "Dynamin at actin tails.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 161–6. 2002. doi:10.1073/pnas.012607799. PMID 11782545. 
• "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. 2002. doi:10.1074/jbc.M202783200. PMID 12029088. 
• "Dynamin2 and cortactin regulate actin assembly and filament organization.". Curr. Biol. 12 (21): 1852–7. 2003. doi:10.1016/S0960-9822(02)01228-9. PMID 12419186. 
• "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.". J. Biol. Chem. 278 (6): 4160–7. 2003. doi:10.1074/jbc.M208568200. PMID 12456676. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Reduction in the minimum candidate interval in the dominant-intermediate form of Charcot-Marie-Tooth neuropathy to D19S586 to D19S432.". Neurogenetics 4 (2): 83–5. 2003. doi:10.1007/s10048-002-0139-3. PMID 12481986. 
• Aniko, Gal (2015). "The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.". Clinical Neuropathology 32 (2): 89–95. doi:10.5414/NP300789. PMID 25492887. http://real.mtak.hu/29088/1/34._Gal_A_et_al_Clinical_Neuropathology._2015_34_89_95_u.pdf. 

External links

• GeneReviews/NIH/NCBI/UW entry on DNM2-Related Intermediate Charcot-Marie-Tooth Neuropathy or AD Charcot-Marie-Tooth Disease Type 2B
• HGNC Approved Gene Symbol: DNM2, Cytogenetic location: 19p13.2,Genomic coordinates (GRCh38): 19:10,718,052-10,831,909 (from NCBI)