Biology:SHANK1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.

Interactions

SHANK1 has been shown to interact with:

• ARHGEF7,
• BAIAP2,
• DNM2,
• SPTAN1, and
• Somatostatin receptor 2.

Further reading

• "The Shank family of scaffold proteins.". J. Cell Sci. 113 (11): 1851–6. 2000. doi:10.1242/jcs.113.11.1851. PMID 10806096. 
• "Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.". Neuron 23 (3): 569–82. 1999. doi:10.1016/S0896-6273(00)80809-0. PMID 10433268. 
• "Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.". Neuron 23 (3): 583–92. 1999. doi:10.1016/S0896-6273(00)80810-7. PMID 10433269. 
• "The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family.". J. Biol. Chem. 275 (46): 36204–10. 2000. doi:10.1074/jbc.M006448200. PMID 10958799. 
• "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. 2000. doi:10.1074/jbc.C000490200. PMID 10964907. 
• "Identification of proteins interacting with the rat somatostatin receptor subtype 2.". J. Physiol. Paris 94 (3–4): 193–8. 2001. doi:10.1016/S0928-4257(00)00204-7. PMID 11087996. 
• "Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins". Mol. Cell. Neurosci. 17 (2): 385–97. 2001. doi:10.1006/mcne.2000.0940. PMID 11178875. 
• "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. 2001. doi:10.1074/jbc.M102454200. PMID 11509555. 
• "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. 2002. doi:10.1074/jbc.M104927200. PMID 11583995. 
• "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. 2003. doi:10.1006/mcne.2002.1201. PMID 12504591. 
• "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. 2003. doi:10.1074/jbc.M301052200. PMID 12626503. 
• "Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse". J. Gastroenterol. Hepatol. 18 (6): 712–8. 2004. doi:10.1046/j.1440-1746.2003.03046.x. PMID 12753155. 
• "Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization". J. Biol. Chem. 278 (48): 48099–104. 2004. doi:10.1074/jbc.M306919200. PMID 12954649. 
• "A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins". Eur. J. Neurosci. 21 (2): 339–50. 2005. doi:10.1111/j.1460-9568.2005.03856.x. PMID 15673434. 
• "The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms". J. Biol. Chem. 280 (51): 42315–24. 2006. doi:10.1074/jbc.M507155200. PMID 16192279.