Biology:SMCP
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene.[1][2]
Function
Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.[2]
References
- ↑ "Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP)". Genomics 32 (2): 184–90. Mar 1996. doi:10.1006/geno.1996.0104. PMID 8833144.
- ↑ 2.0 2.1 "Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4184.
Further reading
- "Mammalian selenium-containing proteins". Annual Review of Nutrition 21: 453–73. 2001. doi:10.1146/annurev.nutr.21.1.453. PMID 11375445.
- "Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons". DNA and Cell Biology 11 (9): 693–9. Nov 1992. doi:10.1089/dna.1992.11.693. PMID 1418626.
- "Semen selenium content and sperm mitochondrial volume in human and some animal species". Human Reproduction 4 (3): 304–8. Apr 1989. doi:10.1093/oxfordjournals.humrep.a136893. PMID 2715306.
- "Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm". Molecular Reproduction and Development 45 (3): 320–31. Nov 1996. doi:10.1002/(SICI)1098-2795(199611)45:3<320::AID-MRD9>3.0.CO;2-U. PMID 8916043.
- "Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats". Biology of Reproduction 61 (2): 428–35. Aug 1999. doi:10.1095/biolreprod61.2.428. PMID 10411523.
- "Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene". Molecular and Cellular Biology 22 (9): 3046–52. May 2002. doi:10.1128/MCB.22.9.3046-3052.2002. PMID 11940662.
- "Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene". Genomics 87 (3): 382–91. Mar 2006. doi:10.1016/j.ygeno.2005.09.010. PMID 16325371.
- "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics 15 (23): 3411–9. Dec 2006. doi:10.1093/hmg/ddl417. PMID 17047026.
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