Biology:ZNF182
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zinc finger protein 182 is a protein that in humans is encoded by the ZNF182 gene.[1][2][3][4]
Model organisms
Model organisms have been used in the study of ZNF182 function. A conditional knockout mouse line called Zfp182tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11] - in-depth bone and cartilage phenotyping[12]
| Characteristic | Phenotype |
|---|---|
| All data available at.[6][11][12] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Haematology 6 Weeks | Normal |
| Insulin | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
| Influenza Challenge | Normal |
| Trichuris Challenge | Normal |
References
- ↑ "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics 21 (1): 180–7. May 1994. doi:10.1006/geno.1994.1240. PMID 8088786.
- ↑ "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics 48 (4): 726–40. Apr 1991. PMID 2014798.
- ↑ "Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization". Somatic Cell and Molecular Genetics 22 (3): 237–9. May 1996. doi:10.1007/BF02369914. PMID 8914609.
- ↑ "Entrez Gene: ZNF182 zinc finger protein 182". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7569.
- ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ 6.0 6.1 "International Mouse Phenotyping Consortium". http://www.mousephenotype.org/data/search?q=Zfp182#fq=*:*&facet=gene.
- ↑ "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. Jun 2011. doi:10.1038/nature10163. PMID 21677750.
- ↑ "Mouse library set to be knockout". Nature 474 (7351): 262–3. Jun 2011. doi:10.1038/474262a. PMID 21677718.
- ↑ "A mouse for all reasons". Cell 128 (1): 9–13. Jan 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. Jul 2013. doi:10.1016/j.cell.2013.06.022. PMID 23870131.
- ↑ 11.0 11.1 "Infection and Immunity Immunophenotyping (3i) Consortium". http://www.immunophenotyping.org/data/search?keys=Zfp182&field_gene_construct_tid=All.
- ↑ 12.0 12.1 "OBCD Consortium". http://www.boneandcartilage.com/.
Further reading
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. Jun 2004. doi:10.1038/nbt971. PMID 15146197.
- "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist 2 (4): 363–74. Apr 1990. PMID 2288909.
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