Biology:NUAK2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an enzyme that in humans is encoded by the NUAK2 gene.[1][2] Its deficiency in humans causes anencephaly, a severe form of anterior neural tube defect that curtails brain development.[3]
References
- ↑ "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- ↑ "Entrez Gene: NUAK2 NUAK family, SNF1-like kinase, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81788.
- ↑ "A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling". The Journal of Experimental Medicine 217 (12). December 2020. doi:10.1084/jem.20191561. PMID 32845958.
Further reading
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK.". Biochem. J. 355 (Pt 2): 297–305. 2001. doi:10.1042/0264-6021:3550297. PMID 11284715.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family.". Biochem. Biophys. Res. Commun. 311 (1): 156–61. 2004. doi:10.1016/j.bbrc.2003.09.184. PMID 14575707.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833–43. 2005. doi:10.1038/sj.emboj.7600110. PMID 14976552.
- "Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness.". J. Biol. Chem. 279 (45): 46742–7. 2004. doi:10.1074/jbc.M404334200. PMID 15345718.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
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