Biology:CNOT4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.

Further reading

• "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal 26 (3): 1239–50. March 2012. doi:10.1096/fj.11-195875. PMID 22159038. 
• "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology 337 (1): 157–65. March 2004. doi:10.1016/j.jmb.2004.01.031. PMID 15001359. 
• "Human Ccr4-Not complexes contain variable deadenylase subunits". The Biochemical Journal 422 (3): 443–53. September 2009. doi:10.1042/BJ20090500. PMID 19558367. https://hal.archives-ouvertes.fr/hal-00479183/file/PEER_stage2_10.1042%252FBJ20090500.pdf. 
• "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal 21 (3): 355–64. February 2002. doi:10.1093/emboj/21.3.355. PMID 11823428. 
• "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure 12 (4): 633–44. April 2004. doi:10.1016/j.str.2004.03.004. PMID 15062086. 
• "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision 8: 205–20. June 2002. PMID 12107410. 
• "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development 23 (8): 951–62. April 2009. doi:10.1101/gad.1769209. PMID 19346402. 
• "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry 276 (13): 10185–90. March 2001. doi:10.1074/jbc.M009298200. PMID 11087754. 
• "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research 28 (3): 809–17. February 2000. doi:10.1093/nar/28.3.809. PMID 10637334. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.