Biology:CNOT1
From HandWiki
 Generic protein structure example |
| CCR4-Not complex component, Not1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Not1 | ||||||||
| Pfam | PF04054 | ||||||||
| InterPro | IPR007196 | ||||||||
| |||||||||
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.[1][2]
It is a part of the CCR4-Not complex, which deadenylates mRNAs.[3] CNOT1 acts as a scaffold protein, binding other subunits of the complex.[4][5][6]
Interactions
CNOT1 has been shown to interact with CNOT8.[7][8]
References
- ↑ "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics 36 (1): 40–5. January 2004. doi:10.1038/ng1285. PMID 14702039.
- ↑ "Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23019.
- ↑ "The highways and byways of mRNA decay". Nat. Rev. Mol. Cell Biol. 8 (2): 113–26. Feb 2007. doi:10.1038/nrm2104. PMID 17245413.
- ↑ "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin". Nucleic Acids Res. 39 (10): 4373–86. May 2011. doi:10.1093/nar/gkr011. PMID 21278420.
- ↑ "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex". Nucleic Acids Res. 40 (21): 11058–72. Nov 2012. doi:10.1093/nar/gks883. PMID 22977175.
- ↑ "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction". Mol. Cell 48 (2): 207–18. Oct 26, 2012. doi:10.1016/j.molcel.2012.08.014. PMID 22959269.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. February 2000. doi:10.1093/nar/28.3.809. PMID 10637334.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. 1999. doi:10.1093/dnares/6.1.63. PMID 10231032.
- "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex". J. Mol. Biol. 314 (4): 683–94. 2001. doi:10.1006/jmbi.2001.5162. PMID 11733989.
- "A two-step strategy for constructing specifically self-subtracted cDNA libraries". Nucleic Acids Res. 30 (9): 38e–38. 2002. doi:10.1093/nar/30.9.e38. PMID 11972353.
- "Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription". EMBO J. 25 (13): 3089–99. 2006. doi:10.1038/sj.emboj.7601194. PMID 16778766.
External links
- Eukaryotic Linear Motif resource motif class LIG_CNOT1_NIM_1
- Human CNOT1 genome location and CNOT1 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: A5YKK6 (CCR4-NOT transcription complex subunit 1) at the PDBe-KB.
 |
