Biology:SEPP1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[1][2]

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues (human, rat, mouse)[3] per polypeptide, one located at the C-terminal side of protein and others at the N-terminal side. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[2]

Animal models

Mice and dogs with knock-out variants in their SEPP1 homologues (Selenop[4] and SELENOP[5] respectively) may develop cerebellar ataxia phenotypes.[6][7] SEPP1 and neural precursor cell levels in mouse brains increase post-exercise. Mice engineered to lack SEPP1 did not increase neural precursors.[8][9]

See also

References

  1. ↑ "Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA". Proceedings of the National Academy of Sciences of the United States of America 90 (2): 537–541. January 1993. doi:10.1073/pnas.90.2.537. PMID 8421687. Bibcode: 1993PNAS...90..537H. 
  2. ↑ 2.0 2.1 "Entrez Gene: SEPP1 selenoprotein P, plasma, 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6414. 
  3. ↑ Burk and Hill 2009
  4. ↑ "Selenop selenoprotein P [Mus musculus (house mouse) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/20363. 
  5. ↑ "SELENOP selenoprotein P [Canis lupus familiaris (dog) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/479346. 
  6. ↑ "Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs". PLOS Genetics 17 (8): e1009716. August 2021. doi:10.1371/journal.pgen.1009716. PMID 34339417. 
  7. ↑ "Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues". The Biochemical Journal 370 (Pt 2): 397–402. March 2003. doi:10.1042/bj20021853. PMID 12521380. 
  8. ↑ PÉREZ ORTEGA, RODRIGO (February 3, 2022). "Widely available supplement may explain brain boost from exercise" (in en). https://www.science.org/content/article/widely-available-supplement-may-explain-brain-boost-exercise. 
  9. ↑ Leiter, Odette; Zhuo, Zhan; Rust, Ruslan; Wasielewska, Joanna M.; Grönnert, Lisa; Kowal, Susann; Overall, Rupert W.; Adusumilli, Vijay S. et al. (3 February 2022). "Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging" (in en). Cell Metabolism 34 (3): 408–423.e8. doi:10.1016/j.cmet.2022.01.005. PMID 35120590. 

Further reading

  • "Selenoprotein P. A selenium-rich extracellular glycoprotein". The Journal of Nutrition 124 (10): 1891–1897. October 1994. doi:10.1093/jn/124.10.1891. PMID 7931697. 
  • "Selenoprotein P: properties, functions, and regulation". Archives of Biochemistry and Biophysics 376 (2): 433–438. April 2000. doi:10.1006/abbi.2000.1735. PMID 10775431. 
  • "The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame". The Journal of Biological Chemistry 266 (16): 10050–10053. June 1991. doi:10.1016/S0021-9258(18)99185-4. PMID 2037562. 
  • "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • "Purification of selenoprotein P from human plasma". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1204 (2): 243–249. February 1994. doi:10.1016/0167-4838(94)90014-0. PMID 8142465. 
  • "Human selenoprotein P gene maps to 5q31". Genomics 36 (3): 550–551. September 1996. doi:10.1006/geno.1996.0505. PMID 8884283. 
  • "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • "A novel method for the purification of selenoprotein P from human plasma". Archives of Biochemistry and Biophysics 357 (2): 326–330. September 1998. doi:10.1006/abbi.1998.0809. PMID 9735174. 
  • "Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p". The Journal of Biological Chemistry 274 (5): 2866–2871. January 1999. doi:10.1074/jbc.274.5.2866. PMID 9915822. 
  • "Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry". Analytical Biochemistry 267 (1): 84–91. February 1999. doi:10.1006/abio.1998.2949. PMID 9918658. 
  • "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance". Biological Chemistry 381 (3): 265–268. March 2000. doi:10.1515/BC.2000.034. PMID 10782998. 
  • "Heparin-binding histidine and lysine residues of rat selenoprotein P". The Journal of Biological Chemistry 276 (19): 15823–15831. May 2001. doi:10.1074/jbc.M010405200. PMID 11278668. 
  • "Association of selenoprotein P with testosterone production in cultured Leydig cells". Archives of Andrology 47 (1): 67–76. 2001. doi:10.1080/01485010152104026. PMID 11442337. 
  • "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency". European Journal of Human Genetics 10 (9): 499–504. September 2002. doi:10.1038/sj.ejhg.5200811. PMID 12173025. 
  • "Characterization of selenoprotein P as a selenium supply protein". European Journal of Biochemistry 269 (22): 5746–5751. November 2002. doi:10.1046/j.1432-1033.2002.03298.x. PMID 12423375. 



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