Biology:TEX14
Testis-expressed protein 14 is a protein in humans encoded by the TEX14 gene, and is 1497 amino acids in length.[1] TEX14 plays a vital role in the formation of germ cells, as it is an essential component of the mammalian germ cell interphase bridge.[2]
An orthologue of TEX14 exists in other mammals, also called TEX14.
Function
During cell division, specifically in telophase, the spindle is converted into a midbody. This midbody contains a ring of TEX14, which gradually travels outwards as cell division progresses. Finally, TEX14 marks the ends of the intercellular bridge.[3]
Clinical significance
Male mice and male pigs that lack normal TEX14 are incapable of producing functional sperm, and thus are infertile.[2][4] However, TEX14-knockout female mice are not infertile.[5]
References
- ↑ "TEX14 Gene - GeneCards | TEX14 Protein | TEX14 Antibody". https://www.genecards.org/cgi-bin/carddisp.pl?gene=TEX14.
- ↑ 2.0 2.1 "TEX14 is essential for intercellular bridges and fertility in male mice". Proceedings of the National Academy of Sciences of the United States of America 103 (13): 4982–4987. March 2006. doi:10.1073/pnas.0505123103. PMID 16549803. Bibcode: 2006PNAS..103.4982G.
- ↑ "Conversion of midbodies into germ cell intercellular bridges". Developmental Biology 305 (2): 389–396. May 2007. doi:10.1016/j.ydbio.2007.02.025. PMID 17383626.
- ↑ "An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs". BMC Genomics 12 (1): 591. December 2011. doi:10.1186/1471-2164-12-591. PMID 22136159.
- ↑ "Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility". Biology of Reproduction 80 (3): 449–457. March 2009. doi:10.1095/biolreprod.108.070649. PMID 19020301.
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