Biology:NDN (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Necdin is a protein that in humans is encoded by the NDN gene.[1][2]
Function
This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mice suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.[2]
Necdin is used to stimulate growth regulation and DNA-dependent transcription regulation.[3]
Interactions
NDN (gene) has been shown to interact with:
- E2F1,[4][5]
- HNRNPU,[6]
- IL1A,[7]
- Low affinity nerve growth factor receptor,[5][8][9]
- NUCB2,[10] and
- P53[11]
References
- ↑ "The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse". Hum Mol Genet 6 (11): 1873–8. January 1998. doi:10.1093/hmg/6.11.1873. PMID 9302265.
- ↑ 2.0 2.1 "Entrez Gene: NDN necdin homolog (mouse)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4692.
- ↑ Uniprot
- ↑ "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. January 1998. doi:10.1074/jbc.273.2.720. PMID 9422723.
- ↑ 5.0 5.1 "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. January 2004. doi:10.1074/jbc.M308454200. PMID 14593116.
- ↑ "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. 2002. doi:10.1002/jcb.10047. PMID 11813259.
- ↑ "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. August 2003. doi:10.1073/pnas.1737765100. PMID 12913118. Bibcode: 2003PNAS..10010008H.
- ↑ "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. April 2003. doi:10.1523/JNEUROSCI.23-08-03209.2003. PMID 12716928.
- ↑ "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. December 2002. doi:10.1074/jbc.C200533200. PMID 12414813.
- ↑ "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. October 2000. doi:10.1074/jbc.M005103200. PMID 10915798.
- ↑ "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. June 1999. doi:10.1074/jbc.274.23.16242. PMID 10347180.
Further reading
- "Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain.". Brain Res. Dev. Brain Res. 68 (2): 265–74. 1992. doi:10.1016/0165-3806(92)90069-9. PMID 1394972.
- "The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region.". Nat. Genet. 17 (3): 357–61. 1997. doi:10.1038/ng1197-357. PMID 9354807.
- "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.". J. Biol. Chem. 273 (2): 720–8. 1998. doi:10.1074/jbc.273.2.720. PMID 9422723.
- "The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region.". Gene 213 (1–2): 65–72. 1998. doi:10.1016/S0378-1119(98)00206-6. PMID 9630521.
- "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. 1999. doi:10.1074/jbc.274.23.16242. PMID 10347180.
- "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. 2000. doi:10.1074/jbc.M005103200. PMID 10915798.
- "Cellular and subcellular localization of necdin in fetal and adult mouse brain". Dev. Neurosci. 22 (4): 310–9. 2000. doi:10.1159/000017455. PMID 10965153.
- "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. 2002. doi:10.1002/jcb.10047. PMID 11813259.
- "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. 2002. doi:10.1074/jbc.M109728200. PMID 11959851.
- "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells". J. Biol. Chem. 277 (44): 42128–35. 2003. doi:10.1074/jbc.M205024200. PMID 12198120.
- "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. 2003. doi:10.1074/jbc.C200533200. PMID 12414813.
- "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. 2003. doi:10.1523/JNEUROSCI.23-08-03209.2003. PMID 12716928.
- "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. 2003. doi:10.1073/pnas.1737765100. PMID 12913118. Bibcode: 2003PNAS..10010008H.
- "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. 2004. doi:10.1074/jbc.M308454200. PMID 14593116.
- "Tissue-specific and imprinted epigenetic modifications of the human NDN gene". Nucleic Acids Res. 32 (11): 3376–82. 2004. doi:10.1093/nar/gkh671. PMID 15247330.
- "Negative regulation of hypoxia inducible factor-1alpha by necdin". FEBS Lett. 579 (17): 3797–801. 2005. doi:10.1016/j.febslet.2005.05.072. PMID 15978586.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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