Biology:Mammaglobin-A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.[1][2][3]
Function
SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.[4]
Clinical significance
SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.[5]
References
- ↑ "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13". Oncogene 16 (6): 817–24. Mar 1998. doi:10.1038/sj.onc.1201597. PMID 9488047.
- ↑ "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer". Cancer Res 56 (4): 860–5. Jul 1996. PMID 8631025.
- ↑ "Entrez Gene: SCGB2A2 secretoglobin, family 2A, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4250.
- ↑ "Evaluation of expression based markers for the detection of breast cancer cells". Breast Cancer Research and Treatment 97 (1): 41–47. 2006. doi:10.1007/s10549-005-9085-8. PMID 16319979.
- ↑ "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer (Bioscientifica) 13 (4): 1033–1067. 2006. doi:10.1677/ERC-06-0001. PMID 17158753.
Further reading
- "Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.". J. Exp. Med. 187 (1): 59–70. 1998. doi:10.1084/jem.187.1.59. PMID 9419211.
- "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.". Eur. J. Immunol. 28 (9): 2971–7. 1998. doi:10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3. PMID 9754584.
- "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer.". Biochemistry 41 (21): 6714–22. 2002. doi:10.1021/bi0159884. PMID 12022875.
- "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. 2003. doi:10.1038/nm822. PMID 12539042.
- "Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients.". Int. J. Cancer 108 (4): 592–5. 2004. doi:10.1002/ijc.11609. PMID 14696125.
- "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes.". Am. J. Clin. Pathol. 121 (5): 637–43. 2004. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203.
- "Mammaglobin expression in leukapheresis products is a predictive marker of poor prognosis in women with high-risk breast cancer.". Clin. Cancer Res. 10 (18 Pt 1): 6039–46. 2005. doi:10.1158/1078-0432.CCR-03-0453. PMID 15447988.
- "Mammaglobin a in breast cancer: existence of multiple molecular forms.". Int. J. Cancer 114 (4): 623–7. 2005. doi:10.1002/ijc.20780. PMID 15609337.
- "Human mammaglobin mRNA is a reliable molecular marker for detecting occult breast cancer cells in peripheral blood.". J. Exp. Clin. Cancer Res. 24 (2): 265–71. 2005. PMID 16110760.
- "Mammaglobin as molecular marker of breast cancer (micro)metastases.". Clin. Cancer Res. 11 (19 Pt 1): 7043–7044. 2006. doi:10.1158/1078-0432.CCR-05-1378. PMID 16203799.
- "Relationship between human mammaglobin mRNA expression in breast cancer tissue and clinico-pathologic features of the tumors.". J. Exp. Clin. Cancer Res. 25 (1): 65–72. 2006. PMID 16761620.
- "Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR.". Clin. Biochem. 39 (9): 879–87. 2007. doi:10.1016/j.clinbiochem.2006.06.009. PMID 16925986.
- "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category.". Eur J Surg Oncol 33 (1): 16–22. 2007. doi:10.1016/j.ejso.2006.09.013. PMID 17071045.
- "Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers.". Mod. Pathol. 20 (2): 208–14. 2007. doi:10.1038/modpathol.3800731. PMID 17192791.
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