Biology:PRB3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.[1][2]
The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.[2]
References
- ↑ "Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein". J Biol Chem 266 (26): 17358–68. Oct 1991. doi:10.1016/S0021-9258(19)47381-X. PMID 1894623.
- ↑ 2.0 2.1 "Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5544.
Further reading
- "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. 17. 1988. 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2.
- "Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew.". Am. J. Hum. Genet. 47 (4): 686–97. 1990. PMID 2171329.
- "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.". Genetics 120 (1): 267–78. 1989. doi:10.1093/genetics/120.1.267. PMID 2851479.
- "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.". J. Biol. Chem. 260 (20): 11123–30. 1985. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- "PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro.". Infect. Immun. 61 (10): 4434–9. 1993. doi:10.1128/IAI.61.10.4434-4439.1993. PMID 8406834.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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