Biology:COX6C
 Generic protein structure example |
Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.[1][2]
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.[2]
References
- ↑ "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet 83 (3–4): 226–7. Mar 1999. doi:10.1159/000015185. PMID 10072584.
- ↑ 2.0 2.1 "Entrez Gene: COX6C cytochrome c oxidase subunit VIc". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1345.
External links
- Human COX6C genome location and COX6C gene details page in the UCSC Genome Browser.
Further reading
- "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol.. Progress in Nucleic Acid Research and Molecular Biology 61: 309–44. 1998. doi:10.1016/S0079-6603(08)60830-2. ISBN 9780125400619. PMID 9752724.
- "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457–65. 2007. doi:10.1515/BC.2007.059. PMID 17516841.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700–7. 1999. doi:10.1046/j.1471-4159.1999.0720700.x. PMID 9930743.
- "Two differentially expressed genes in normal human prostate tissue and in carcinoma.". Cancer Res. 56 (16): 3634–7. 1996. PMID 8705997.
- "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc.". Nucleic Acids Res. 16 (22): 10916. 1989. doi:10.1093/nar/16.22.10916. PMID 2849755.
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