Biology:Lateral olfactory tract usher substance
Lateral olfactory tract usher substance (LOTUS), also known as Cartilage acidic protein-1B (Crtac1B), is a membrane protein produced by neurons. During embryonic development, it is strongly expressed in the olfactory bulb by Mitral cells.[1]
Function
LOTUS is an endogenous antagonist of the Nogo receptor (NgR1) and Paired Immunoglobulin-Like Receptor B (PirB in mice, LilrB2 in humans). These receptors block neuronal outgrowth when activated. By blocking their function, LOTUS promotes neuronal growth, e.g. during the formation of the lateral olfactory tract.[2] As LOTUS generates a permissive brain environment for neuronal regeneration, it may aid recovery after spinal cord injury. It also has been shown to reduce synapse loss in a mouse model of Alzheimer's disease.[3]
References
- ↑ "Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation". Science 333 (6043): 769–773. August 2011. doi:10.1126/science.1204144. PMID 21817055. Bibcode: 2011Sci...333..769S.
- ↑ "LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice". PLOS ONE 12 (9): e0184258. 2017-09-07. doi:10.1371/journal.pone.0184258. PMID 28880879. Bibcode: 2017PLoSO..1284258T.
- ↑ "LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB". Molecular Medicine 28 (1): 154. December 2022. doi:10.1186/s10020-022-00581-7. PMID 36510132.
 |  |
