Biology:CLEC1B
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Short description: Protein-coding gene in humans
 Generic protein structure example |
C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.[1][2][3]
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][3]
References
- ↑ "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol 30 (2): 697–704. Mar 2000. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
- ↑ "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol 31 (12): 3493–503. Dec 2001. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369.
- ↑ 3.0 3.1 "Entrez Gene: CLEC1B C-type lectin domain family 1, member B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51266.
External links
- Human CLEC1B genome location and CLEC1B gene details page in the UCSC Genome Browser.
- Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood 107 (2): 542–9. 2006. doi:10.1182/blood-2005-05-1994. PMID 16174766.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Crystallization and X-ray diffraction analysis of human CLEC-2". Acta Crystallographica Section F 61 (Pt 12): 1094–6. 2006. doi:10.1107/S1744309105037991. PMID 16511244.
- "The finished DNA sequence of human chromosome 12". Nature 440 (7082): 346–51. 2006. doi:10.1038/nature04569. PMID 16541075. Bibcode: 2006Natur.440..346S.
- "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets". J. Virol. 80 (18): 8951–60. 2006. doi:10.1128/JVI.00136-06. PMID 16940507.
- "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem. 282 (5): 3165–72. 2007. doi:10.1074/jbc.M610383200. PMID 17132623.
- "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem. 282 (36): 25993–6001. 2007. doi:10.1074/jbc.M702327200. PMID 17616532.
- "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2". Protein Science 17 (9): 1611–6. 2008. doi:10.1110/ps.035568.108. PMID 18583525.
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