Biology:DAPK3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.

Interactions

DAPK3 has been shown to interact with PAWR and Death associated protein 6.

Further reading

• "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization". Journal of Human Genetics 43 (3): 209–11. 1998. doi:10.1007/s100380050073. PMID 9747039. 
• "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells". FEBS Letters 451 (1): 81–4. May 1999. doi:10.1016/S0014-5793(99)00550-5. PMID 10356987. 
• "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis". FEBS Letters 462 (1–2): 187–91. Nov 1999. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117. 
• "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis". Oncogene 18 (51): 7265–73. Dec 1999. doi:10.1038/sj.onc.1203170. PMID 10602480. 
• "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Molecular and Cellular Biology 22 (20): 6959–70. Oct 2002. doi:10.1128/MCB.22.20.6959-6970.2002. PMID 12242277. 
• "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Research 31 (3): 878–85. Feb 2003. doi:10.1093/nar/gkg176. PMID 12560483. 
• "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology 23 (17): 6174–86. Sep 2003. doi:10.1128/MCB.23.17.6174-6186.2003. PMID 12917339. 
• "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1". Journal of Molecular Biology 337 (1): 115–28. Mar 2004. doi:10.1016/j.jmb.2003.10.081. PMID 15001356. 
• "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase". The Journal of Biological Chemistry 279 (40): 42055–61. Oct 2004. doi:10.1074/jbc.M403676200. PMID 15292222. 
• "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal 19 (2): 267–9. Feb 2005. doi:10.1096/fj.04-1558fje. PMID 15546961. 
• "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3". International Journal of Andrology 28 (3): 163–70. Jun 2005. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542. 
• "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics 3 (10): 1884–93. Oct 2007. doi:10.1371/journal.pgen.0030180. PMID 17953487. 
• "Novel ZIP kinase isoform lacks leucine zipper". Archives of Biochemistry and Biophysics 456 (2): 194–203. Dec 2006. doi:10.1016/j.abb.2006.09.026. PMID 17126281.