Biology:Activated protein C–protein C inhibitor
Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI).[1][2][3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications.[2][3][4] It is a marker of thrombin generation and indicates hypercoagulability.[1][5] The half-life of APC-PCI is either 40 minutes or 140 minutes.[1] Ethinylestradiol-containing birth control pills have been found to increase levels of APC-PCI to a similar degree as thrombin–antithrombin complex (TAT) and to a greater extent than D-dimer.[5] However, only APC-PCI was able to differentiate between a second- and third-generation birth control pill.[5]
Another complex related to APC-PCI is the activated protein C–α1-antitrypsin (APCAT) complex.[1]
References
- ↑ 1.0 1.1 1.2 1.3 "Laboratory Measurement of Thrombin Activity--What Every Clinician Scientist Needs to Know". J Thromb Thrombolysis 2 (2): 85–92. 1995. doi:10.1007/BF01064374. PMID 10608009.
- ↑ 2.0 2.1 "Biochemical markers for the diagnosis of venous thromboembolism: the past, present and future". J Thromb Thrombolysis 30 (4): 459–71. November 2010. doi:10.1007/s11239-010-0460-x. PMID 20213258.
- ↑ 3.0 3.1 "Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm". J Vasc Surg 54 (3): 865–78. September 2011. doi:10.1016/j.jvs.2011.04.010. PMID 21684711.
- ↑ "Blood-based protein biomarkers for stroke differentiation: A systematic review". Proteomics Clin Appl 11 (9–10). September 2017. doi:10.1002/prca.201700007. PMID 28452132.
- ↑ 5.0 5.1 5.2 "The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives". Thromb Res 130 (4): 636–9. October 2012. doi:10.1016/j.thromres.2011.11.006. PMID 22154243.
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