Biology:RNA of unknown function
From HandWiki
RNA of unknown function (RUF) is a generic name, often appended with a numeric identifier, for a non-coding RNA molecule which has been partially characterised or predicted but the biological function has yet to be determined. The same convention is used for proteins, they can be named domains of unknown function (DUFs).
Examples of RUFs include:
- RUF1–8 found in Saccharomyces cerevisiae,[2] though three of these were later reclassified due to experimental errors[3]
- RUF20–23 also from S. cerevisiae[1]
- RUF1–6 found in Plasmodium falciparum in 2007[4]
References
- ↑ 1.0 1.1 "Non-coding RNA prediction and verification in Saccharomyces cerevisiae". PLOS Genet. 5 (1): e1000321. January 2009. doi:10.1371/journal.pgen.1000321. PMID 19119416.
- ↑ "Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics". Nucleic Acids Res. 31 (14): 4119–4128. July 2003. doi:10.1093/nar/gkg438. PMID 12853629.
- ↑ McCutcheon, J. P.; Eddy, S. R. (2004). "Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics". Nucleic Acids Research 32 (15): 4119–4128. doi:10.1093/nar/gkh801. PMID 12853629.
- ↑ "Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis". RNA 13 (11): 1923–1939. November 2007. doi:10.1261/rna.751807. PMID 17901154. PMC 2040097. http://www.rnajournal.org/cgi/pmidlookup?view=long&pmid=17901154. Retrieved 2010-09-16.
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