Biology:2-hydroxychromene-2-carboxylate isomerase

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Short description: Class of enzymes
2-hydroxychromene-2-carboxylate isomerase
Identifiers
EC number5.99.1.4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

2-hydroxychromene-2-carboxylate isomerase (EC 5.99.1.4, HCCA isomerase, 2HC2CA isomerase, 2-hydroxychromene-2-carboxylic acid isomerase) is an enzyme with systematic name 2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2-hydroxy-2H-chromene-2-carboxylate [math]\displaystyle{ \rightleftharpoons }[/math] (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate

This enzyme is involved in naphthalene degradation.

References

  1. "Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2". Journal of Biochemistry 124 (3): 591–7. September 1998. doi:10.1093/oxfordjournals.jbchem.a022152. PMID 9722670. 
  2. "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology 152 (Pt 7): 1929–40. July 2006. doi:10.1099/mic.0.28783-0. PMID 16804169. 
  3. "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". Journal of Bacteriology 176 (24): 7757–62. December 1994. doi:10.1128/jb.176.24.7757-7762.1994. PMID 8002605. 
  4. "2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida". Biochemistry 46 (23): 6710–22. June 2007. doi:10.1021/bi700356u. PMID 17508726. 

External links