Biology:DUSP16
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.[1][2][3][4]
The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.[supplied by OMIM][4]
Interactions
DUSP16 has been shown to interact with MAPK14[5][6] and MAPK8IP1.[7]
References
- ↑ "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J Biol Chem 276 (28): 26629–39. Jul 2001. doi:10.1074/jbc.M101981200. PMID 11359773.
- ↑ "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J Biol Chem 276 (42): 39002–11. Oct 2001. doi:10.1074/jbc.M104600200. PMID 11489891.
- ↑ "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2". J Biol Chem 280 (27): 25651–8. Jul 2005. doi:10.1074/jbc.M501926200. PMID 15888437.
- ↑ 4.0 4.1 "Entrez Gene: DUSP16 dual specificity phosphatase 16". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80824.
- ↑ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. (United States) 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.
- ↑ Masuda, K; Shima H; Watanabe M; Kikuchi K (Oct 2001). "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein". J. Biol. Chem. (United States) 276 (42): 39002–11. doi:10.1074/jbc.M104600200. ISSN 0021-9258. PMID 11489891.
- ↑ Willoughby, Emma A; Perkins Gordon R; Collins Mary K; Whitmarsh Alan J (Mar 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. (United States) 278 (12): 10731–6. doi:10.1074/jbc.M207324200. ISSN 0021-9258. PMID 12524447.
Further reading
- "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. 2001. doi:10.1093/dnares/7.6.347. PMID 11214970.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.". J. Biol. Chem. 278 (12): 10731–6. 2003. doi:10.1074/jbc.M207324200. PMID 12524447.
- "Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.". J. Biol. Chem. 278 (34): 32448–56. 2003. doi:10.1074/jbc.M213254200. PMID 12794087.
- "MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation.". Oncogene 22 (49): 7728–36. 2003. doi:10.1038/sj.onc.1207089. PMID 14586399.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Phosphorylation of Ser-446 determines stability of MKP-7.". J. Biol. Chem. 280 (15): 14716–22. 2005. doi:10.1074/jbc.M500200200. PMID 15689616.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 16
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