Biology:Parathyroid hormone family
From HandWiki
| Parathyroid hormone family | |||||||||
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| Identifiers | |||||||||
| Symbol | Parathyroid | ||||||||
| Pfam | PF01279 | ||||||||
| InterPro | IPR001415 | ||||||||
| PROSITE | PDOC00296 | ||||||||
| SCOP2 | 1zwg / SCOPe / SUPFAM | ||||||||
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The parathyroid hormone family is a family of structurally and functionally related proteins. Parathyroid hormone (PTH) is a polypeptidic hormone primarily involved in calcium metabolism. The parathyroid hormone-related protein (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by mammary glands into the circulation and increase bone turnover.[1][2] PTH and PTH-rP bind to the same G-protein coupled receptor.[3] The related protein PTH-L has been found in teleost fish, which also have two forms of PTH and PTHrP.[4] Three subfamilies can be identified: PTH, PTHrP and PTH-L.[5]
Human proteins containing this domain
- PTH
- PTHLH
References
- ↑ "Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation". J. Clin. Invest. 112 (9): 1429–36. November 2003. doi:10.1172/JCI19504. PMID 14597768.
- ↑ "Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine". J. Bone Miner. Res. 27 (6): 1231–9. June 2012. doi:10.1002/jbmr.1617. PMID 22549910.
- ↑ "Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action". Recent Prog. Horm. Res. 45: 467–502; discussion 502–6. 1989. doi:10.1016/b978-0-12-571145-6.50014-5. ISBN 9780125711456. PMID 2682846.
- ↑ "Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken". BMC Evol. Biol. 10: 373. 2010. doi:10.1186/1471-2148-10-373. PMID 21122104.
- ↑ "The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish". Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2): R679–96. February 2007. doi:10.1152/ajpregu.00480.2006. PMID 17023665.
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