Biology:S-SodF RNA
| SodF sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of SodF small RNA | |
| Identifiers | |
| Rfam | RF02790 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0017148, 0003729, 0043488 |
| SO | 0000370 |
| PDB structures | PDBe |
s-SodF RNA is a non-coding RNA (ncRNA) molecule identified in Streptomyces coelicolor. It is produced from sodF mRNA by cleavage of about 90 nucleotides from its 3′UTR. However it does not affect the function of sodF mRNA, but It acts on another mRNA called sodN. s-SodF RNA has a sequence complementary to sodN mRNA from the 5′-end up to the ribosome binding site. It pairs with sodN mRNA, blocks its translation and facilitates sodN mRNA decay.[1] In Streptomyces sodF and sodN genes produce FeSOD and NiSOD superoxide dismutases containing Fe and Ni respectively. Their expression is inversely regulated by nickel-specific Fur-family regulator called Nur. When Ni is present Nur directly represses sodF transcription, and indirectly induces sodN.[2][3][4][5][6]
References
- ↑ "Inverse regulation of Fe- and Ni-containing SOD genes by a Fur family regulator Nur through small RNA processed from 3′UTR of the sodF mRNA". Nucleic Acids Research 42 (3): 2003–2014. February 2014. doi:10.1093/nar/gkt1071. PMID 24234448.
- ↑ "Expression and regulation of the sodF gene encoding iron- and zinc-containing superoxide dismutase in Streptomyces coelicolor Müller". Journal of Bacteriology 180 (8): 2014–2020. April 1998. doi:10.1128/JB.180.8.2014-2020.1998. PMID 9555880.
- ↑ "Transcriptional and post-transcriptional regulation by nickel of sodN gene encoding nickel-containing superoxide dismutase from Streptomyces coelicolor Müller". Molecular Microbiology 27 (1): 187–195. January 1998. doi:10.1046/j.1365-2958.1998.00674.x. PMID 9466266.
- ↑ "Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor". Molecular Microbiology 59 (6): 1848–1858. March 2006. doi:10.1111/j.1365-2958.2006.05065.x. PMID 16553888.
- ↑ "Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition". Nucleic Acids Research 37 (10): 3442–3451. June 2009. doi:10.1093/nar/gkp198. PMID 19336416.
- ↑ "Negative regulation of the gene for Fe-containing superoxide dismutase by an Ni-responsive factor in Streptomyces coelicolor". Journal of Bacteriology 181 (23): 7381–7384. December 1999. doi:10.1128/JB.181.23.7381-7384.1999. PMID 10572144.
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