Biology:BRSK2

Short description: Protein-coding gene in the species Homo sapiens

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.^[1]^[2]^[3]

References

↑ "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics 43 (4): 283–4. Jan 1999. doi:10.1007/s100380050092. PMID 9852686.
↑ "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics 44 (1): 1–9. Mar 1999. doi:10.1007/s100380050096. PMID 9929968.
↑ "Entrez Gene: BRSK2 BR serine/threonine kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9024.

"Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast 18 (1): 69–80. Jan 2001. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal 23 (4): 833–43. Feb 2004. doi:10.1038/sj.emboj.7600110. PMID 14976552.
"Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function". The Journal of Biological Chemistry 279 (30): 31164–70. Jul 2004. doi:10.1074/jbc.M404728200. PMID 15150265.
"BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis". Journal of Neuroimmunology 170 (1–2): 186–90. Dec 2005. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222.
"SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release". Neuron 50 (2): 261–75. Apr 2006. doi:10.1016/j.neuron.2006.03.018. PMID 16630837.
"BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260". Biochemical and Biophysical Research Communications 347 (4): 867–71. Sep 2006. doi:10.1016/j.bbrc.2006.06.178. PMID 16870137.

Human BRSK2 genome location and BRSK2 gene details page in the UCSC Genome Browser.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)