Biology:EGOT (gene)
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EGOT, also known as Eosinophil Granule Ontogeny (EGO)† Transcript (non-protein coding),[1] is a human gene at 3p26.1 that produces a long noncoding RNA molecule. EGOT is nested within an intron of the inositol triphosphate receptor type 1 (ITPR1) gene. The EGOT transcript is expressed during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.[1] Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.[2]
†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.[3]
References
- ↑ 1.0 1.1 "EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression". Blood 109 (12): 5191–5198. June 2007. doi:10.1182/blood-2006-06-027987. PMID 17351112.
- ↑ "Molecular evolution of the non-coding eosinophil granule ontogeny transcript". Front Genet 2: 69. October 2011. doi:10.3389/fgene.2011.00069. PMID 22303364.
- ↑ Wright, MW (Apr 9, 2014). "A short guide to long non-coding RNA gene nomenclature.". Human Genomics 8 (1): 7. doi:10.1186/1479-7364-8-7. PMID 24716852.
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