Chemistry:Maytansinoid

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A maytansinoid is a chemical derivative of maytansine.[1] Some are being investigated as the cytotoxic component of antibody-drug conjugates.[1] Anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytansinoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppresses their dynamic instability[2]

Examples:

  • Ansamitocin[3]
  • Mertansine/emtansine (DM1)
  • ravtansine/soravtansine (DM4)

See also

  • ImmunoGen Inc, developer of maytansinoid based drugs.

References

  1. ↑ 1.0 1.1 Chari, RV et al. (January 1992). "Immunoconjugates containing novel maytansinoids: promising anticancer drugs.". Cancer Res. 52: 127–31. PMID 1727373. http://cancerres.aacrjournals.org/content/52/1/127.full.pdf. 
  2. ↑ Lopus, M; Oroudjev, E; Wilson, L; Wilhelm, S; Widdison, W; Chari, R; Jordan, MA (2010). "Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules". Mol Cancer Ther 9: 2689–99. doi:10.1158/1535-7163.MCT-10-0644. PMID 20937594. 
  3. ↑ Yu, TW et al. (June 2002). "The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum". Proc. Natl. Acad. Sci. U.S.A. 99: 7968–73. doi:10.1073/pnas.092697199. PMID 12060743. PMC 123004. http://www.pnas.org/content/99/12/7968.abstract. 





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