Chemistry:Satavaptan

Satavaptan
Clinical data
ATC code	none;
Identifiers
	IUPAC name N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide;
CAS Number	185913-78-4 ;
PubChem CID	9810773;
ChemSpider	32699105 ;
UNII	AJS8S3P31H;
Chemical and physical data
Formula	C33H45N3O8S
Molar mass	643.80 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1COCCN1CCO[C@H]2CC[C@](CC2)3c4cc(OCC)ccc4N(C3=O)S(=O)(=O)c5ccc(cc5OC)C(=O)NC(C)(C)C;
	InChI InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+ ; Key:QKXJWFOKVQWEDZ-VCCCEUOBSA-N ;
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Short description: Chemical compound

Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist^[1] which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites.^[2] Development was discontinued in 2009.^[3]

References

↑ "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clinical Journal of the American Society of Nephrology 1 (6): 1154–60. November 2006. doi:10.2215/CJN.00160106. PMID 17699341.
↑ "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial". Hepatology 48 (1): 204–13. July 2008. doi:10.1002/hep.22293. PMID 18508290.
↑ "Satavaptan". Adis Insight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800007591.

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Original source: https://en.wikipedia.org/wiki/Satavaptan. Read more

[pmid17699341-1] "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clinical Journal of the American Society of Nephrology 1 (6): 1154–60. November 2006. doi:10.2215/CJN.00160106. PMID 17699341.

[pmid18508290-2] "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial". Hepatology 48 (1): 204–13. July 2008. doi:10.1002/hep.22293. PMID 18508290.

[AdisInsight-3] "Satavaptan". Adis Insight. Springer Nature Switzerland AG. http://adisinsight.springer.com/drugs/800007591.

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Clinical data

ATC code	none
Identifiers
IUPAC name N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide
CAS Number	185913-78-4^Y
PubChem CID	9810773
ChemSpider	32699105^N
UNII	AJS8S3P31H
Chemical and physical data
Formula	C₃₃H₄₅N₃O₈S
Molar mass	643.80 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1COCCN1CCO[C@H]2CC[C@](CC2)3c4cc(OCC)ccc4N(C3=O)S(=O)(=O)c5ccc(cc5OC)C(=O)NC(C)(C)C
InChI InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+^N Key:QKXJWFOKVQWEDZ-VCCCEUOBSA-N^N
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