Chemistry:DCPG

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Short description: Chemical
DCPG
DCPG structure.png
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
FormulaC10H9NO6
Molar mass239.183 g·mol−1
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR8. It has anticonvulsant effects in animal studies,[1][2] and has also been investigated as a possible treatment for hyperalgesia.[3]

References

  1. "Glutamate metabotropic receptors as targets for drug therapy in epilepsy". European Journal of Pharmacology 476 (1–2): 3–16. August 2003. doi:10.1016/s0014-2999(03)02149-6. PMID 12969743. 
  2. "Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid". Neuropharmacology 54 (4): 665–75. March 2008. doi:10.1016/j.neuropharm.2007.11.015. PMID 18191956. 
  3. "Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice". Neuropharmacology 52 (2): 253–62. February 2007. doi:10.1016/j.neuropharm.2006.04.006. PMID 17113112.