Biology:MENTAL domain
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Revision as of 23:02, 12 August 2022 by imported>John Stpola (fixing)
| MENTAL domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | MENTAL | ||||||||
| Pfam | PF10457 | ||||||||
| InterPro | IPR019498 | ||||||||
| PROSITE | PS51439 | ||||||||
| |||||||||
The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO.[1] The domain is 170 amino acids long.
Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves.[2] The domain may also direct cholesterol transport.
References
- ↑ "MENTHO, a MLN64 Homologue Devoid of the START Domain.". J. Biol. Chem. 277 (18): 50780–7. 2002. doi:10.1074/jbc.M208290200. PMID 12393907.
- ↑ "Functional characterization of the MENTAL domain.". J. Biol. Chem. 280 (18): 17945–52. 2005. doi:10.1074/jbc.M500723200. PMID 15718238.
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