Biology:Sialic acid acetylesterase
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Sialic acid acetylesterase (SIAE) is an enzyme that produces 9-O acetylated sialic acid e.g. in mammals. It down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance e.g. in mice.[1] Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.[1]
References
- ↑ 1.0 1.1 Ira Surolia (8 July 2010). "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity". Nature 466 (7303): 243–247. doi:10.1038/nature09115. PMID 20555325.
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