Biology:VqmR sRNA
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Revision as of 03:17, 24 May 2022 by imported>Raymond Straus (simplify)
| VqmR sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of VqmR small RNA | |
| Identifiers | |
| Rfam | RF02834 |
| Other data | |
| Domain(s) | Bacteria |
| GO | 0042710, 0040033, 0003729 |
| SO | 0000370 |
| PDB structures | PDBe |
VqmR small RNA was discovered in Vibrio cholerae, a bacterium which can cause cholera, using differential RNA sequencing (sRNA-seq) under conditions of low and high cell density which were being used to study quorum sensing (QS).[1] QS controls virulence and biofilm formation in Vibrio cholerae; it has been shown previously that it is directed by the Qrr sRNAs.[2][3] VqmR has been shown to repress the expression of multiple mRNAs including the rtx (repeats in toxin) toxin genes and the vpsT , which is required for biofilm formation. In fact, VqmR which is highly conserved in vibrionaceae, was shown to strongly inhibit biofilm formation by repressing the vpsT gene; it could be the link between biofilm formation and QS.[1]
References
- ↑ 1.0 1.1 "Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation". Proceedings of the National Academy of Sciences of the United States of America 112 (7): E766–775. February 2015. doi:10.1073/pnas.1500203112. PMID 25646441.
- ↑ "The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae". Cell 118 (1): 69–82. July 2004. doi:10.1016/j.cell.2004.06.009. PMID 15242645.
- ↑ "The Vibrio cholerae quorum sensing response is mediated by Hfq-dependent sRNA/mRNA base pairing interactions". Molecular Microbiology 80 (5): 1381–1394. June 2011. doi:10.1111/j.1365-2958.2011.07655.x. PMID 21453446.
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