Biology:MEG8

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Short description: Non-coding RNA in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

In molecular biology, Maternally expressed 8 (non-protein coding), also known as MEG8 or Rian (RNA Imprinted and Accumulated in Nucleus), is a long non-coding RNA. It is an imprinted gene, which is maternally expressed. It is expressed in the nucleus and (in an eight-week-old sheep) is preferentially expressed in skeletal muscle.[1][2]

See also

  • Long noncoding RNA

References

  1. "Identification of a new imprinted gene, Rian, on mouse chromosome 12 by fluorescent differential display screening". Journal of Biochemistry 130 (2): 187–90. August 2001. doi:10.1093/oxfordjournals.jbchem.a002971. PMID 11481034. 
  2. "Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8". Genome Research 11 (5): 850–62. May 2001. doi:10.1101/gr.172701. PMID 11337479. 

Further reading

  • "Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region". Human Molecular Genetics 11 (13): 1527–38. June 2002. doi:10.1093/hmg/11.13.1527. PMID 12045206.