Medicine:Winterbottom's sign
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| Winterbottom's sign | |
|---|---|
| Differential diagnosis | African trypanosomiasis |
Winterbottom's sign is a swelling of lymph nodes (lymphadenopathy) along the posterior cervical lymph node chain, associated with the early phase of African trypanosomiasis (African sleeping sickness), a disease caused by the parasites Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. It may be suggestive of cerebral infection.[1] Winterbottom reported about the slave traders who, apparently aware of the ominous sign of swollen cervical lymph glands, used to palpate the necks of the slaves before buying them.[2][3][4]
The sign was first reported by the English physician Thomas Masterman Winterbottom in 1803.[citation needed]
References
- ↑ Ormerod WE (October 1991). "Hypothesis: the significance of Winterbottom's sign". J Trop Med Hyg 94 (5): 338–40. PMID 1942213.
- ↑ "The history of sleeping sickness". https://www.who.int/trypanosomiasis_african/country/history/en/index4.html.
- ↑ Miles, Tom. "The Winterbottom Catalogue". http://www.bl.uk/aboutus/acrossuk/worknat/full/Projects/winterbottom/index.html.
- ↑ Cox F. History of sleeping sickness (African trypanosomiasis). Infectious Disease Clinics of North America - Volume 18, Issue 2 (June 2004)
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