Medicine:Lymphadenopathy

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Short description: Disease of lymph nodes
Lymphadenopathy
Other namesAdenopathy, swollen lymph nodes, swollen glands
CT of axillary lymphadenopathy - annotated.jpg
A CT scan of axillary lymphadenopathy in a 57-year-old man with multiple myeloma.
SpecialtyInfectious disease, Oncology
Symptomsfever; Hard, fixed, rapidly growing nodes, indicating a possible cancer or lymphoma; night sweats; Runny nose; sore throat
Causesinfections; autoimmune diseases; malignancies; histiocytoses; storage diseases; benign hyperplasia; drug reactions
Risk factorsback pain; constipation; urinary frequency
Diagnostic methodCT scan; MRI scan; ultrasound

Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency. Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis,[1] producing swollen or enlarged lymph nodes. In clinical practice, the distinction between lymphadenopathy and lymphadenitis is rarely made and the words are usually treated as synonymous. Inflammation of the lymphatic vessels is known as lymphangitis.[2] Infectious lymphadenitis affecting lymph nodes in the neck is often called scrofula.

Lymphadenopathy is a common and nonspecific sign. Common causes include infections (from minor causes such as the common cold and post-vaccination swelling to serious ones such as HIV/AIDS), autoimmune diseases, and cancer. Lymphadenopathy is frequently idiopathic and self-limiting.

Causes

Retroperitoneal lymphadenopathies of testicular seminoma embrace the aorta. Computed tomography image.

Lymph node enlargement is recognized as a common sign of infectious, autoimmune, or malignant disease. Examples may include:

Infectious causes of lymphadenopathy may include bacterial infections such as cat scratch disease, tularemia, brucellosis, or prevotella, as well as fungal infections such as paracoccidioidomycosis.[14][15]

Benign (reactive) lymphadenopathy

Benign lymphadenopathy is a common biopsy finding, and may often be confused with malignant lymphoma. It may be separated into major morphologic patterns, each with its own differential diagnosis with certain types of lymphoma. Most cases of reactive follicular hyperplasia are easy to diagnose, but some cases may be confused with follicular lymphoma. There are seven distinct patterns of benign lymphadenopathy:[6]

  • Follicular hyperplasia: This is the most common type of reactive lymphadenopathy.[6]
  • Paracortical hyperplasia/Interfollicular hyperplasia: It is seen in viral infections, skin diseases, and nonspecific reactions.
  • Sinus histiocytosis: It is seen in lymph nodes draining limbs, inflammatory lesions, and malignancies.
  • Nodal extensive necrosis
  • Nodal granulomatous inflammation
  • Nodal extensive fibrosis (Connective tissue framework)
  • Nodal deposition of interstitial substance

These morphological patterns are never pure. Thus, reactive follicular hyperplasia can have a component of paracortical hyperplasia. However, this distinction is important for the differential diagnosis of the cause.

Diagnosis

Medical ultrasonography of a typical normal lymph node: smooth, gently lobulated oval with a hypoechoic cortex measuring less than 3 mm in thickness with a central echogenic hilum.[26]
Ultrasonography of a suspected malignant lymph node:
- Absence of the fatty hilum
- Increased focal cortical thickness greater than 3 cm
- Doppler ultrasonography that shows hyperaemic blood flow in the hilum and central cortex and/or abnormal (non-hilar cortical) blood flow.[26]

In cervical lymphadenopathy (of the neck), it is routine to perform a throat examination including the use of a mirror and an endoscope.[27]

On ultrasound, B-mode imaging depicts lymph node morphology, whilst power Doppler can assess the vascular pattern.[28] B-mode imaging features that can distinguish metastasis and lymphoma include size, shape, calcification, loss of hilar architecture, as well as intranodal necrosis.[28] Soft tissue edema and nodal matting on B-mode imaging suggests tuberculous cervical lymphadenitis or previous radiation therapy.[28] Serial monitoring of nodal size and vascularity are useful in assessing treatment response.[28]

Fine-needle aspiration cytology (FNAC) has sensitivity and specificity percentages of 81% and 100%, respectively, in the histopathology of malignant cervical lymphadenopathy.[27] PET-CT has proven to be helpful in identifying occult primary carcinomas of the head and neck, especially when applied as a guiding tool prior to panendoscopy, and may induce treatment related clinical decisions in up to 60% of cases.[27]

Classification

Lymphadenopathy may be classified by:

  • Size, where lymphadenopathy in adults is often defined as a short axis of one or more lymph nodes is greater than 10mm.[29]
  • By extent:
    • Localized lymphadenopathy: due to localized spot of infection; e.g., an infected spot on the scalp will cause lymph nodes in the neck on that same side to swell up
Inflammatory localized lymphadenopathy at right mandibular angle
    • Generalized lymphadenopathy: due to a systemic infection of the body; e.g., influenza or secondary syphilis
      • Persistent generalized lymphadenopathy (PGL): persisting for a long time, possibly without an apparent cause
  • By localization:
  • Dermatopathic lymphadenopathy: lymphadenopathy associated with skin disease.
  • By malignancy: Benign lymphadenopathy is distinguished from malignant types which mainly refer to lymphomas or lymph node metastasis.

Size

Long and short axis.png
Micrograph of dermatopathic lymphadenopathy, a type of lymphadenopathy. H&E stain.
  • By size, where lymphadenopathy in adults is often defined as a short axis of one or more lymph nodes is greater than 10mm.[29][30] However, there is regional variation as detailed in this table:
Upper limit of lymph node sizes in adults
Generally 10 mm[29][30]
Inguinal 10[31] – 20 mm[32]
Pelvis 10 mm for ovoid lymph nodes, 8 mm for rounded[31]
Neck
Generally (non-retropharyngeal) 10 mm[31][33]
Jugulodigastric lymph nodes 11mm[31] or 15 mm[33]
Retropharyngeal 8 mm[33]
  • Lateral retropharyngeal: 5 mm[31]
Mediastinum
Mediastinum, generally 10 mm[31]
Superior mediastinum and high paratracheal 7mm[34]
Low paratracheal and subcarinal 11 mm[34]
Upper abdominal
Retrocrural space 6 mm[35]
Paracardiac 8 mm[35]
Gastrohepatic ligament 8 mm[35]
Upper paraaortic region 9 mm[35]
Portacaval space 10 mm[35]
Porta hepatis 7 mm[35]
Lower paraaortic region 11 mm[35]

Lymphadenopathy of the axillary lymph nodes can be defined as solid nodes measuring more than 15 mm without fatty hilum.[36] Axillary lymph nodes may be normal up to 30 mm if consisting largely of fat.[36]

In children, a short axis of 8 mm can be used.[37] However, inguinal lymph nodes of up to 15 mm and cervical lymph nodes of up to 20 mm are generally normal in children up to age 8–12.[38]

Lymphadenopathy of more than 1.5–2 cm increases the risk of cancer or granulomatous disease as the cause rather than only inflammation or infection. Still, an increasing size and persistence over time are more indicative of cancer.[39]

See also

References

  1. ↑ "lymphadenitis" at Dorland's Medical Dictionary
  2. ↑ "lymphangitis" at Dorland's Medical Dictionary
  3. ↑ Fontanilla, JM; Barnes, A; Von Reyn, CF (September 2011). "Current diagnosis and management of peripheral tuberculous lymphadenitis". Clinical Infectious Diseases 53 (6): 555–562. doi:10.1093/cid/cir454. PMID 21865192. 
  4. ↑ Klotz, SA; Ianas, V; Elliott, SP (2011). "Cat-scratch Disease". American Family Physician 83 (2): 152–155. PMID 21243990. http://www.aafp.org/afp/2011/0115/p152.html. 
  5. ↑ Butler, T (2009). "Plague into the 21st century". Clinical Infectious Diseases 49 (5): 736–742. doi:10.1086/604718. PMID 19606935. 
  6. ↑ 6.0 6.1 6.2 Weiss, LM; O'Malley, D (2013). "Benign lymphadenopathies". Modern Pathology 26 (Supplement 1): S88–S96. doi:10.1038/modpathol.2012.176. PMID 23281438. 
  7. ↑ Sweeney, DA; Hicks, CW; Cui, X; Li, Y; Eichacker, PQ (December 2011). "Anthrax infection". American Journal of Respiratory and Critical Care Medicine 184 (12): 1333–1341. doi:10.1164/rccm.201102-0209CI. PMID 21852539. 
  8. ↑ Kennedy, PG (February 2013). "Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)". Lancet Neurology 12 (2): 186–194. doi:10.1016/S1474-4422(12)70296-X. PMID 23260189. 
  9. ↑ 9.0 9.1 9.2 Status and anamnesis, Anders Albinsson. Page 12
  10. ↑ Kim, TU; Kim, S; Lee, JW; Lee, NK; Jeon, UB; Ha, HG; Shin, DH (September–October 2012). "Plasma cell type of Castleman's disease involving renal parenchyma and sinus with cardiac tamponade: case report and literature review". Korean Journal of Radiology 13 (5): 658–663. doi:10.3348/kjr.2012.13.5.658. PMID 22977337. 
  11. ↑ Zhang, H; Wang, R; Wang, H; Xu, Y; Chen, J (June 2012). "Membranoproliferative glomerulonephritis in Castleman's disease: a systematic review of the literature and 2 case reports". Internal Medicine (Tokyo, Japan) 51 (12): 1537–1542. doi:10.2169/internalmedicine.51.6298. PMID 22728487. 
  12. ↑ Bratucu, E; Lazar, A; Marincaş, M; Daha, C; Zurac, S (March–April 2013). "Aseptic mesenteric lymph node abscesses. In search of an answer. A new entity?". Chirurgia (Bucarest, Romania: 1990) 108 (2): 152–160. PMID 23618562. http://revistachirurgia.ro/pdfs/2013-2-152.pdf. 
  13. ↑ Leung, A; Sigalet, DL (June 2003). "Acute Abdominal Pain in Children". American Family Physician 67 (11): 2321–2327. PMID 12800960. http://www.aafp.org/afp/2003/0601/p2321.html. 
  14. ↑ Cordova, LA; Torres, J (19 September 2022). "Paracoccidioidomycosis". StatPearls [Internet]. Treasure Island (FL). PMID 33085335. 
  15. ↑ Marques, Sílvio Alencar (1 November 2012). "Paracoccidioidomycosis". Clinics in Dermatology 30 (6): 610–615. doi:10.1016/j.clindermatol.2012.01.006. PMID 23068148. 
  16. ↑ Glass, C (September 2008). "Role of the Primary Care Physician in Hodgkin Lymphoma". American Family Physician 78 (5): 615–622. PMID 18788239. http://www.aafp.org/afp/2008/0901/p615.html. 
  17. ↑ Colon, NC; Chung, DH (2011). "Neuroblastoma". Advances in Pediatrics 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMID 21736987. 
  18. ↑ Sagatys, EM; Zhang, L (January 2011). "Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia". Cancer Control 19 (1): 18–25. doi:10.1177/107327481201900103. PMID 22143059. 
  19. ↑ Melikoglu, MA; Melikoglu, M (October–December 2008). "The clinical importance of lymphadenopathy in systemic lupus erythematosus". Acta Reumatologia Portuguesa 33 (4): 402–406. PMID 19107085. http://www.actareumatologica.pt/oldsite/conteudo/pdfs/ARP_2008_4_402_07__AR_-_Lymphadenopathy.pdf. 
  20. ↑ Lederman, MM; Margolis, L (June 2008). "The lymph node in HIV pathogenesis". Seminars in Immunology 20 (3): 187–195. doi:10.1016/j.smim.2008.06.001. PMID 18620868. 
  21. ↑ Quan, D (October 2012). "North American poisonous bites and stings". Critical Care Clinics 28 (4): 633–659. doi:10.1016/j.ccc.2012.07.010. PMID 22998994. 
  22. ↑ Komagamine, T; Nagashima, T; Kojima, M; Kokubun, N; Nakamura, T; Hashimoto, K; Kimoto, K; Hirata, K (September 2012). "Recurrent aseptic meningitis in association with Kikuchi-Fujimoto disease: case report and literature review". BMC Neurology 12: 187–195. doi:10.1186/1471-2377-12-112. PMID 23020225. 
  23. ↑ Noguchi, S; Yatera, K; Shimajiri, S; Inoue, N; Nagata, S; Nishida, C; Kawanami, T; Ishimoto, H et al. (2012). "Intrathoracic Rosai-Dorfman disease with spontaneous remission: a clinical report and a review of the literature". The Tohoku Journal of Experimental Medicine 227 (3): 231–235. doi:10.1620/tjem.227.231. PMID 22789970. https://www.jstage.jst.go.jp/article/tjem/227/3/227_231/_pdf. 
  24. ↑ Weiss, PF (April 2012). "Pediatric vasculitis". Pediatric Clinics of North America 59 (2): 407–423. doi:10.1016/j.pcl.2012.03.013. PMID 22560577. 
  25. ↑ Koh, H; Kamiishi, N; Chiyotani, A; Takahashi, H; Sudo, A; Masuda, Y; Shinden, S; Tajima, A et al. (April 2012). "Eosinophilic lung disease complicated by Kimura's disease: a case report and literature review". Internal Medicine (Tokyo, Japan) 51 (22): 3163–3167. doi:10.2169/internalmedicine.51.8600. PMID 23154725. https://www.jstage.jst.go.jp/article/internalmedicine/51/22/51_51.8600/_pdf. 
  26. ↑ 26.0 26.1 Dialani, V.; James, D. F.; Slanetz, P. J. (2014). "A practical approach to imaging the axilla". Insights into Imaging 6 (2): 217–229. doi:10.1007/s13244-014-0367-8. ISSN 1869-4101. PMID 25534139.  Creative Commons attribution license
  27. ↑ 27.0 27.1 27.2 Balm, A. J. M.; van Velthuysen, M. L. F.; Hoebers, F. J. P.; Vogel, W. V.; van den Brekel, M. W. M. (2010). "Diagnosis and Treatment of a Neck Node Swelling Suspicious for a Malignancy: An Algorithmic Approach". International Journal of Surgical Oncology 2010: 1–8. doi:10.1155/2010/581540. ISSN 2090-1402. PMID 22312490. 
  28. ↑ 28.0 28.1 28.2 28.3 Ahuja, A.T. (2008). "Ultrasound of malignant cervical lymph nodes". Cancer Imaging 8 (1): 48–56. doi:10.1102/1470-7330.2008.0006. ISSN 1470-7330. PMID 18390388. 
  29. ↑ 29.0 29.1 29.2 Ganeshalingam, Skandadas; Koh, Dow-Mu (2009). "Nodal staging". Cancer Imaging 9 (1): 104–111. doi:10.1102/1470-7330.2009.0017. ISSN 1470-7330. PMID 20080453. 
  30. ↑ 30.0 30.1 Schmidt Júnior, Aurelino Fernandes; Rodrigues, Olavo Ribeiro; Matheus, Roberto Storte; Kim, Jorge Du Ub; Jatene, Fábio Biscegli (2007). "Distribuição, tamanho e número dos linfonodos mediastinais: definições por meio de estudo anatômico". Jornal Brasileiro de Pneumologia 33 (2): 134–140. doi:10.1590/S1806-37132007000200006. ISSN 1806-3713. PMID 17724531. 
  31. ↑ 31.0 31.1 31.2 31.3 31.4 31.5 "Current concepts in lymph node imaging". Journal of Nuclear Medicine 45 (9): 1509–18. September 2004. PMID 15347718. 
  32. ↑ "Assessment of lymphadenopathy". http://bestpractice.bmj.com/best-practice/monograph/838/diagnosis/step-by-step.html.  Last updated: Last updated: Feb 16, 2017
  33. ↑ 33.0 33.1 33.2 Page 432 in: Luca Saba (2016). Image Principles, Neck, and the Brain. CRC Press. ISBN 9781482216202. 
  34. ↑ 34.0 34.1 Sharma, Amita; Fidias, Panos; Hayman, L. Anne; Loomis, Susanne L.; Taber, Katherine H.; Aquino, Suzanne L. (2004). "Patterns of Lymphadenopathy in Thoracic Malignancies". RadioGraphics 24 (2): 419–434. doi:10.1148/rg.242035075. ISSN 0271-5333. PMID 15026591. 
  35. ↑ 35.0 35.1 35.2 35.3 35.4 35.5 35.6 Dorfman, R E; Alpern, M B; Gross, B H; Sandler, M A (1991). "Upper abdominal lymph nodes: criteria for normal size determined with CT.". Radiology 180 (2): 319–322. doi:10.1148/radiology.180.2.2068292. ISSN 0033-8419. PMID 2068292. 
  36. ↑ 36.0 36.1 Page 559 in: Wolfgang Dähnert (2011). Radiology Review Manual. Lippincott Williams & Wilkins. ISBN 9781609139438. 
  37. ↑ Page 942 in: Richard M. Gore, Marc S. Levine (2010). High Yield Imaging Gastrointestinal HIGH YIELD in Radiology. Elsevier Health Sciences. ISBN 9781455711444. 
  38. ↑ Laurence Knott. "Generalised Lymphadenopathy". http://patient.info/doctor/generalised-lymphadenopathy.  Last checked: 24 March 2014
  39. ↑ "Lymphadenopathy and malignancy". American Family Physician 66 (11): 2103–10. December 2002. PMID 12484692. 

External links

Classification
External resources



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