Medicine:Isolated organ perfusion technique

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Short description: Medical procedure

Isolated organ perfusion technique is employed to precipitate an organ's perfusion and circulation that are independent/isolated from the body's systemic circulation for various purposes such as organ-localized chemotherapy, organ-targeted delivery of drug, gene or anything else, organ transplantation, and organ injury recovery. The technique has been widely studied in animal and human for decades.[1][2][3][4][5][6][7] Before the implementation, the perfusion system will be selected and the process can be similar to organ bath.[8] Isolated organ perfusion technique, nevertheless, is averagely conducted in vivo without leaving the organ alone as a whole out of the body.[9]

See also

  • ECMO

References

  1. ↑ Cypel, Marcelo; Keshavjee, Shaf (2016). "Novel Technologies for Isolated Lung Perfusion". Thoracic Surgery Clinics (Elsevier BV) 26 (2): 139–145. doi:10.1016/j.thorsurg.2015.12.002. ISSN 1547-4127. PMID 27112253. 
  2. ↑ Eiseman, B.; Knipe, Peter; McCOLL, H. A.; Orloff, M. J. (1961-09-01). "Isolated Liver Perfusion for Reducing Blood Ammonia". Archives of Surgery 83 (3): 356–363. doi:10.1001/archsurg.1961.01300150030004. ISSN 0004-0010. PMID 13726167. https://jamanetwork.com/journals/jamasurgery/fullarticle/559744. Retrieved 2019-06-30. 
  3. ↑ "Isolated Organ Perfusion Studies - Physiology". https://www.harvardapparatus.com/physiology/isolated-organ-perfusion-studies.html. 
  4. ↑ Abbott, William M.; Weinerth, John L. (1971). "The perfusion of isolated whole organs". Cryobiology (Elsevier BV) 8 (2): 113–133. doi:10.1016/0011-2240(71)90019-8. ISSN 0011-2240. PMID 5578880. 
  5. ↑ Guyette, Jacques P; Gilpin, Sarah E; Charest, Jonathan M; Tapias, Luis F; Ren, Xi; Ott, Harald C (2014-05-29). "Perfusion decellularization of whole organs". Nature Protocols (Springer Science and Business Media LLC) 9 (6): 1451–1468. doi:10.1038/nprot.2014.097. ISSN 1754-2189. PMID 24874812. 
  6. ↑ Schjørring, Olav L.; Carlsson, Rune; Simonsen, Ulf (2015). "Pressure Myography to Study the Function and Structure of Isolated Small Arteries". Methods in Mouse Atherosclerosis. Methods in Molecular Biology. 1339. New York, NY: Springer New York. pp. 277–295. doi:10.1007/978-1-4939-2929-0_19. ISBN 978-1-4939-2928-3. 
  7. ↑ Serrat, Maria A (2009-11-05). "Measuring bone blood supply in mice using fluorescent microspheres". Nature Protocols (Springer Science and Business Media LLC) 4 (12): 1749–1758. doi:10.1038/nprot.2009.190. ISSN 1754-2189. PMID 19893510. 
  8. ↑ "Tissue bath". https://www.harvardapparatus.com/media/harvard/pdf/Perfusion+Systems+Selection+Guide.pdf. 
  9. ↑ Yeh, T.; Wechsler, A. S. (1998). "The Isolated Organ in Research". Surgical Research. New York, NY: Springer New York. pp. 435–452. doi:10.1007/978-1-4612-1888-3_49. ISBN 978-1-4612-7325-7. "Technological advances in artificial perfusion allow effective isolated perfusion of a wide variety of organs and tissues, including, but not limited to, brain, heart, lung, heart-lung, liver, kidney, spleen, pancreas, thymus, gastrointestinal tract, urinary tract, reproductive tract, skeletal muscle, nerves, and blood vessels." 



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