Biology:ANAPC7
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Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[1] Multiple transcript variants encoding different isoforms have been found for this gene.
Function
This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[1]
Interactions
ANAPC7 has been shown to interact with ANAPC1,[2][3] ANAPC4,[2] CDC27[2][4] and CDC20.[2][5]
References
- ↑ 1.0 1.1 "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51434.
- ↑ 2.0 2.1 2.2 2.3 "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. September 2003. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
- ↑ "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. November 2000. doi:10.1083/jcb.151.4.749. PMID 11076961.
- ↑ "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. August 2000. doi:10.1073/pnas.97.16.8973. PMID 10922056.
- ↑ "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. December 2008. doi:10.1038/ncb1799. PMID 18997788.
External links
- Human ANAPC7 genome location and ANAPC7 gene details page in the UCSC Genome Browser.
Further reading
- "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science 279 (5354): 1219–22. 1998. doi:10.1126/science.279.5354.1219. PMID 9469815.
- "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. 1999. doi:10.1074/jbc.274.20.14500. PMID 10318877.
- "Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC". J. Cell Biol. 146 (5): 941–54. 1999. doi:10.1083/jcb.146.5.941. PMID 10477750.
- "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. 1999. doi:10.1073/pnas.96.20.11317. PMID 10500174.
- "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. 2000. doi:10.1073/pnas.97.16.8973. PMID 10922056.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. 2004. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships". Breast Cancer Res. 7 (2): R238–47. 2006. doi:10.1186/bcr978. PMID 15743504.
- "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature 438 (7068): 690–5. 2005. doi:10.1038/nature04151. PMID 16319895.
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