Biology:NOLA2
 Generic protein structure example |
H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.[1][2]
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.
The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10". Mol Cell Biol 20 (23): 9028–40. Dec 2000. doi:10.1128/MCB.20.23.9028-9040.2000. PMID 11074001.
- ↑ 2.0 2.1 "Entrez Gene: NOLA2 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55651.
Further reading
- "Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs.". EMBO J. 17 (23): 7078–90. 1999. doi:10.1093/emboj/17.23.7078. PMID 9843512.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells.". Biochim. Biophys. Acta 1575 (1–3): 31–9. 2002. doi:10.1016/s0167-4781(02)00240-3. PMID 12020816.
- "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. 2003. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins.". EMBO J. 23 (8): 1857–67. 2005. doi:10.1038/sj.emboj.7600181. PMID 15044956.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413.
- "[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer]". Bioorg. Khim. 31 (2): 195–9. 2005. doi:10.1007/s11171-005-0024-6. PMID 15889794.
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