Biology:PIGQ
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Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.[1][2][3]
This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).[3]
Interactions
PIGQ has been shown to interact with PIGH,[1] PIGA[1] and PIGC.[1]
References
- ↑ 1.0 1.1 1.2 1.3 "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J 17 (4): 877–85. Mar 1998. doi:10.1093/emboj/17.4.877. PMID 9463366.
- ↑ "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J 334 (3): 609–16. Nov 1998. doi:10.1042/bj3340609. PMID 9729469.
- ↑ 3.0 3.1 "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9091.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.
- "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. 2005. doi:10.1038/nature03187. PMID 15616553.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis". Gene 271 (2): 247–54. 2001. doi:10.1016/S0378-1119(01)00510-8. PMID 11418246.
- "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. 2001. doi:10.1093/hmg/10.4.339. PMID 11157797.
- "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2". EMBO J. 19 (16): 4402–11. 2000. doi:10.1093/emboj/19.16.4402. PMID 10944123.
- "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis". J. Biol. Chem. 274 (26): 18582–8. 1999. doi:10.1074/jbc.274.26.18582. PMID 10373468.
- "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum". J. Biol. Chem. 271 (43): 26868–75. 1996. doi:10.1074/jbc.271.43.26868. PMID 8900170.
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