Biology:ULBP2
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 Generic protein structure example |
UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6.[1][2] ULBP2 is related to MHC class I molecules, but its gene maps outside the MHC locus.[1][2] The domain structure of ULBP2 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.[1][2]
ULBP2 functions as a stress-induced ligand for the NKG2D killer activation receptor on natural killer cells.[3][2]
References
- ↑ 1.0 1.1 1.2 "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor" (in English). Immunity 14 (2): 123–33. Feb 2001. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
- ↑ 2.0 2.1 2.2 2.3 "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics 79 (1): 114–23. Jan 2002. doi:10.1006/geno.2001.6673. PMID 11827464.
- ↑ "Targeting senescent cells to attenuate cardiovascular disease progression". Ageing Research Reviews 60: 101072. 2020. doi:10.1016/j.arr.2020.101072. PMID 32298812.
Further reading
- "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer". Tissue Antigens 61 (5): 335–43. May 2003. doi:10.1034/j.1399-0039.2003.00070.x. PMID 12753652.
- "A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers". Biochemical and Biophysical Research Communications 285 (2): 235–43. Jul 2001. doi:10.1006/bbrc.2001.5149. PMID 11444831.
- "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family". Immunogenetics 53 (4): 279–87. 2001. doi:10.1007/s002510100325. PMID 11491531.
- "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells". Journal of Immunology 168 (2): 671–9. Jan 2002. doi:10.4049/jimmunol.168.2.671. PMID 11777960.
- "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics 79 (1): 114–23. Jan 2002. doi:10.1006/geno.2001.6673. PMID 11827464.
- "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity". The Journal of Experimental Medicine 197 (11): 1427–39. Jun 2003. doi:10.1084/jem.20022059. PMID 12782710.
- "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology 171 (2): 902–8. Jul 2003. doi:10.4049/jimmunol.171.2.902. PMID 12847260.
- "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D". The Journal of Experimental Medicine 199 (7): 1005–10. Apr 2004. doi:10.1084/jem.20032194. PMID 15051759.
- "Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis". Leukemia Research 31 (10): 1393–402. Oct 2007. doi:10.1016/j.leukres.2007.02.020. PMID 17391757.
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