Biology:WNT3A
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 Generic protein structure example |
Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.[1][2]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc[3] and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.[2]
References
- ↑ "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem Biophys Res Commun 284 (5): 1168–75. Jun 2001. doi:10.1006/bbrc.2001.5105. PMID 11414706.
- ↑ 2.0 2.1 "Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89780.
- ↑ Kennell, Jennifer A.; MacDougald, Ormond A. (24 June 2005). "Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms". Journal of Biological Chemistry 280 (25): 24004–24010. doi:10.1074/jbc.M501080200. PMID 15849360.
Further reading
- "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. 1994. doi:10.1091/mbc.4.12.1267. PMID 8167409.
- "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.". Cancer Res. 54 (10): 2615–21. 1994. PMID 8168088.
- "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.". Oncogene 18 (44): 5959–66. 1999. doi:10.1038/sj.onc.1202985. PMID 10557084.
- "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.". Eur. J. Biochem. 267 (13): 4300–11. 2000. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
- Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
- Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster.". Int. J. Mol. Med. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID 11836627.
- "Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter.". J. Biol. Chem. 277 (36): 33398–410. 2002. doi:10.1074/jbc.M107977200. PMID 12052822.
- "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1–3): 185–9. 2002. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.". J. Biol. Chem. 278 (16): 14066–73. 2003. doi:10.1074/jbc.M213265200. PMID 12556519.
- "Wnt signaling in B-cell neoplasia.". Oncogene 22 (10): 1536–45. 2003. doi:10.1038/sj.onc.1206239. PMID 12629517.
- "Regulation of the Wnt signaling pathway by disabled-2 (Dab2).". EMBO J. 22 (12): 3084–94. 2003. doi:10.1093/emboj/cdg286. PMID 12805222.
- "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.". Mol. Cell. Biol. 23 (16): 5825–35. 2003. doi:10.1128/MCB.23.16.5825-5835.2003. PMID 12897152.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Regulation of casein kinase I epsilon activity by Wnt signaling.". J. Biol. Chem. 279 (13): 13011–7. 2004. doi:10.1074/jbc.M304682200. PMID 14722104.
- "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.". J. Biol. Chem. 279 (17): 17535–42. 2004. doi:10.1074/jbc.M311292200. PMID 14739301.
- "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.". Cell 119 (1): 97–108. 2004. doi:10.1016/j.cell.2004.09.019. PMID 15454084.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.". J. Biol. Chem. 280 (50): 41201–6. 2006. doi:10.1074/jbc.M507004200. PMID 16227623.
- "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. 288 (50): 35651–35659. 2013. doi:10.1074/jbc.M112.437913. PMID 24158438.
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