Biology:UNC5A
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Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.[1]
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM][1]
Interactions
UNC5A has been shown to interact with MAGED1.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90249.
- ↑ "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry 278 (19): 17483–90. May 2003. doi:10.1074/jbc.M300415200. PMID 12598531.
Further reading
- "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer 4 (12): 978–87. December 2004. doi:10.1038/nrc1504. PMID 15573119.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research 8 (6): 319–27. December 2001. doi:10.1093/dnares/8.6.319. PMID 11853319.
- "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry 278 (19): 17483–90. May 2003. doi:10.1074/jbc.M300415200. PMID 12598531.
- "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology 5 (3): 216–23. March 2003. doi:10.1038/ncb943. PMID 12598906.
- "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America 100 (7): 4173–8. April 2003. doi:10.1073/pnas.0738063100. PMID 12655055. Bibcode: 2003PNAS..100.4173T.
- "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry 278 (35): 32561–8. August 2003. doi:10.1074/jbc.M302943200. PMID 12810718.
- "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal 24 (6): 1192–201. March 2005. doi:10.1038/sj.emboj.7600584. PMID 15729359.
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