View source for Biology:(butirosin acyl-carrier protein)—L-glutamate ligase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = (butirosin acyl-carrier protein)—L-glutamate ligase
| EC_number  = 6.2.1.39
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''(Butirosin acyl-carrier protein)—L-glutamate ligase''' ({{EnzExplorer|6.2.1.39}}, ''[BtrI acyl-carrier protein]—L-glutamate ligase'', ''BtrJ'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''(BtrI acyl-carrier protein):L-glutamate ligase (ADP-forming)''.<ref>{{cite journal | vauthors = Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB | title = Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway | journal = Chemistry & Biology | volume = 12 | issue = 6 | pages = 665–75 | date = June 2005 | pmid = 15975512 | doi = 10.1016/j.chembiol.2005.04.010 | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: (1) ATP + L-glutamate + BtrI acyl-carrier protein <math>\rightleftharpoons</math> ADP + [[Chemistry:Phosphate|phosphate]] + L-glutamyl-[BtrI acyl-carrier protein]
: (2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] <math>\rightleftharpoons</math> ADP + phosphate + 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein]

This enzyme catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the [[Chemistry:Butirosin|butirosin]] family.

== References ==
{{reflist}}

== External links ==
* {{MeshName|(butirosin+acyl-carrier+protein)—L-glutamate+ligase}}

{{Ligases CO CS and CN}}
{{Enzymes}}

{{DEFAULTSORT:(butirosin acyl-carrier protein)-L-glutamate ligase}}
[[Category:EC 6.2.1]]

{{Sourceattribution|(butirosin acyl-carrier protein)—L-glutamate ligase}}