Biology:(butirosin acyl-carrier protein)—L-glutamate ligase

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Short description: Class of enzymes
(butirosin acyl-carrier protein)—L-glutamate ligase
Identifiers
EC number6.2.1.39
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

(Butirosin acyl-carrier protein)—L-glutamate ligase (EC 6.2.1.39, [BtrI acyl-carrier protein]—L-glutamate ligase, BtrJ) is an enzyme with systematic name (BtrI acyl-carrier protein):L-glutamate ligase (ADP-forming).[1] This enzyme catalyses the following chemical reaction

(1) ATP + L-glutamate + BtrI acyl-carrier protein [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein]
(2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate + 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein]

This enzyme catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.

References

  1. "Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway". Chemistry & Biology 12 (6): 665–75. June 2005. doi:10.1016/j.chembiol.2005.04.010. PMID 15975512. 

External links