Biology:CAMK2B

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

Function

The enzyme belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signalling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.

Interactions

CAMK2B has been shown to interact with Actinin alpha 4.

Further reading

• "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]". Tanpakushitsu Kakusan Koso 47 (3): 241–7. 2002. PMID 11889801. 
• "Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6337–41. 1988. doi:10.1073/pnas.85.17.6337. PMID 2842767. Bibcode: 1988PNAS...85.6337T. 
• "Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains". J. Biol. Chem. 263 (27): 13486–9. 1988. doi:10.1016/S0021-9258(18)68264-X. PMID 3417668. 
• "Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region. Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms". Eur. J. Biochem. 229 (3): 754–60. 1995. doi:10.1111/j.1432-1033.1995.tb20524.x. PMID 7758473. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor". J. Biol. Chem. 271 (49): 31670–8. 1997. doi:10.1074/jbc.271.49.31670. PMID 8940188. 
• "Identification of novel human tumor cell-specific CaMK-II variants". Biochim. Biophys. Acta 1355 (3): 281–92. 1997. doi:10.1016/S0167-4889(96)00141-3. PMID 9060999. 
• "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. 1997. doi:10.1074/jbc.272.18.11832. PMID 9115241. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Characterization of a calmodulin kinase II inhibitor protein in brain". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10890–5. 1998. doi:10.1073/pnas.95.18.10890. PMID 9724800. Bibcode: 1998PNAS...9510890C. 
• "Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells". Diabetologia 43 (4): 465–73. 2000. doi:10.1007/s001250051330. PMID 10819240. 
• "Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities". FEBS Lett. 475 (2): 107–10. 2000. doi:10.1016/S0014-5793(00)01634-3. PMID 10858498. 
• "Schizophrenia: elevated mRNA for calcium-calmodulin-dependent protein kinase IIbeta in frontal cortex". Brain Res. Mol. Brain Res. 82 (1–2): 95–100. 2001. doi:10.1016/S0169-328X(00)00188-1. PMID 11042361. 
• "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. 2001. doi:10.1523/JNEUROSCI.21-02-00423.2001. PMID 11160423. 
• "Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current". Mol. Pharmacol. 59 (5): 960–4. 2001. doi:10.1124/mol.59.5.960. PMID 11306676. 
• "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56. 2001. doi:10.1016/S0303-7207(01)00383-5. PMID 11325525. 
• "Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus". J. Biol. Chem. 276 (40): 37537–46. 2001. doi:10.1074/jbc.M104101200. PMID 11468283. 
• "Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain. Sequence analyses of human brain calcium/calmodulin-dependent protein kinase II". Mol. Biol. Rep. 28 (1): 35–41. 2002. doi:10.1023/A:1011951814898. PMID 11710563. 
• "NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain". J. Immunol. 168 (1): 95–101. 2002. doi:10.4049/jimmunol.168.1.95. PMID 11751951. 

External links

• Human CAMK2B genome location and CAMK2B gene details page in the UCSC Genome Browser.